Photodynamic Therapy Combined with Ferroptosis Is a Synergistic Antitumor Therapy Strategy.
Autor: | Huang, Yunpeng, Li, Xiaoyu, Zhang, Zijian, Xiong, Li, Wang, Yongxiang, Wen, Yu |
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Předmět: |
LIPID metabolism
IRON metabolism THERAPEUTIC use of antineoplastic agents COMBINATION drug therapy PHOTODYNAMIC therapy CELL membranes PHOTOSENSITIZERS CELL physiology TREATMENT effectiveness NANOSTRUCTURES PATHOLOGIC neovascularization REACTIVE oxygen species CELL death LIPID peroxidation (Biology) NANOPARTICLES |
Zdroj: | Cancers; Oct2023, Vol. 15 Issue 20, p5043, 32p |
Abstrakt: | Simple Summary: In this work, we focused on the synergistic antitumor effects of photodynamic therapy and ferroptosis. First, we briefly introduced the basic theory of ferroptosis and photodynamic therapy. We explored the synergistic anti-tumor effect of photodynamic therapy combined with ferroptosis from a mechanism perspective. Secondly, we introduced the application of photodynamic therapy combined with ferroptosis, which mainly includes the construction of nanomaterials and drug combination. Nanomaterials can exert synergistic effects by activating anti-tumor immunity, improving the hypoxic microenvironment, and inhibiting tumor angiogenesis. The drug combination strategy has good application prospects and clinical significance.We also discussed the shortcomings of existing combination treatment strategies and potential solutions. In conclusion, photodynamic therapy combined with ferroptosis is a promising combination anticancer strategy. Ferroptosis is a programmed death mode that regulates redox homeostasis in cells, and recent studies suggest that it is a promising mode of tumor cell death. Ferroptosis is regulated by iron metabolism, lipid metabolism, and intracellular reducing substances, which is the mechanism basis of its combination with photodynamic therapy (PDT). PDT generates reactive oxygen species (ROS) and 1O |
Databáze: | Complementary Index |
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