Zinc-sensitive MRI contrast agents: importance of local probe accumulation in zinc-rich tissues.

Autor: Malikidogo, Kyangwi P., Isaac, Manon, Uguen, Adrien, Même, Sandra, Pallier, Agnεave;s, Clémençon, Rudy, Morfin, Jean-François, Lacerda, Sara, Tóth, Éva, Bonnet, Célia S.
Předmět:
Zdroj: Chemical Communications; 11/7/2023, Vol. 59 Issue 86, p12883-12886, 4p
Abstrakt: We present the in vitro characterisation of a Gd3+-based contrast agent that responds to Zn2+ upon interaction with Human Serum Albumin. We show that the contradictory in vivo behaviour is related to Gd3+-accumulation in Zn-rich tissues. This highlights the importance of the biodistribution of such contrast agents. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index