| Autor: |
Huang, Chien-Da, Wang, Chun-Hua, Liu, Chien-Ying, Lin, Shu-Min, Chou, Chun-Liang, Liu, Wen-Te, Lin, Horng-Chyuan, Kuo, Han-Pin |
| Předmět: |
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| Zdroj: |
Journal of Asthma; Jun2005, Vol. 42 Issue 5, p395-403, 9p |
| Abstrakt: |
Interleukin (IL)-5 plays an important role in maintaining the survival of eosinophils via the specific a-subunit of its receptor. Apoptosis, a form of programmed cell death, is thought to represent a mechanism that promotes the resolution of eosinophilic inflammation in asthma. The aim of our present study is to investigate whether IL-5 acts in an autocrine fashion on eosinophil apoptosis in asthmatics. Immunoreactivities of intracellular IL-5 and IL-5 receptor a-subunit (Ra) were detected uniquely on the eosinophils. The magnitude of IL-5 and IL-5 Ra expression on eosinophils was significantly higher in asthmatics than that of normal subjects ( p [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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