Association of the HLA region with multiple sclerosis as confirmed by a genome screen using>10,000 SNPs on DNA chips.

Autor:	Gödde, René, Rohde, Klaus, Becker, Christian, Toliat, Mahammad R., Entz, Patricia, Suk, Anita, Müller, Norbert, Sindern, Eckhart, Haupts, Michael, Schimrigk, Sebastian, Nürnberg, Peter, Epplen, Jörg T.
Předmět:	MULTIPLE sclerosis CENTRAL nervous system HLA histocompatibility antigens GENETIC testing DNA GENETIC polymorphisms GENETIC markers
Zdroj:	Journal of Molecular Medicine; Jun2005, Vol. 83 Issue 6, p486-494, 9p
Abstrakt:	Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system, with a complex genetic background. Here, we present a genome screen for association in small scale, employing 11,555 single nucleotide polymorphisms (SNPs) on DNA chips for genotyping 100 MS patients stratified for HLA-DR2+ and 100 controls. More than 500 SNPs revealed significant differences between cases and controls before Bonferroni correction. A fraction of these SNPs was reanalysed in two additional cohorts of patients and controls, using high-throughput genotyping methods. A marker on chromosome 6p21.32 (rs2395182) yielded the highest significance level, validating the established HLA-DR association. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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