| Autor: |
Pang, Yidan, Zhu, Siyuan, Xu, Jun, Su, Cuimin, Wu, Bo, Zhang, Changqing, Gao, Junjie |
| Předmět: |
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| Zdroj: |
Advanced Biology; Oct2023, Vol. 7 Issue 10, p1-9, 9p |
| Abstrakt: |
Brain and bone degenerative diseases such as Alzheimer's disease and osteoporosis are common in the aging population and lack efficient pharmacotherapies. Myeloid cells are a diverse group of mononuclear cells that plays important roles in development, immune defense, and tissue homeostasis. Aging drastically alters the expansion and function of myeloid cells, which might be a common pathogenesis of the brain–bone degenerative diseases. From this perspective, the role of myeloid cells in brain–bone degenerative diseases is discussed, with a particular focus on metabolic alterations in myeloid cells. Furthermore, targeting myeloid cells through metabolic regulation via drugs such as metformin and melatonin is proposed as a potential therapy for the clinical treatment of brain–bone diseases. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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