| Abstrakt: |
Cardiovascular diseases (CVD). the number one cause of death globally, are a group of disorders of heart and blood vessels including hypertension, atherosclerosis, myocardial infarction, ischemic heart disease, and congestive cardiac failure. Risk factors for CVD include genetics, diet, physical activity, stress, weight, gender, and race. Our previous work highlighted the significance of high dietary sugar in endothelial dysfunction, an important event that initiates vascular diseases. Another significant risk factor emerging for CVD is oral microbiome, which plays a crucial role in human health and disease. Healthy oral microbiome harbors commensal bacteria that provide a secondary source of nitric oxide, a molecule involved in maintaining vascular tone. Oral microbiome also harbors pathogenic bacteria like Traponema denticola and Porphorymonas gingivalis that not only cause the gum disease but can also enter the blood as evidenced by their presence in atherosclerotic plaques. Oral microbiome has been studied for many years, but recent advances in -omics technology provides an excellent way to gain deeper insights into the functional microbiome. Oral cavity consists of various niches out of which the tongue coating represents a stable microbiome. In this project, tongue coating microbiome was characterized from four healthy individuals using whole genome sequencing through CosmosID, Inc. Each sample showed the bacterial species diversity of around 110, and a total diversity of more than 200 bacteria] species. One sample showed the presence of Streptococcus sp. and Veillonella sp. which are implicated in cardiovascular disease. This analysis provides an excellent and implementable approach for early intervention in cardiovascular diseases. (This project was supported by Florida Academy of Sciences grant). [ABSTRACT FROM AUTHOR] |
