| Autor: |
Hirner-Eppeneder, Heidrun, Öcal, Elif, Stechele, Matthias, Öcal, Osman, Gu, Sijing, Kimm, Melanie A., Wildgruber, Moritz, Salvermoser, Lukas, Kazmierczak, Philipp, Corradini, Stefanie, Rudelius, Martina, Piontek, Guido, Pech, Maciej, Goldberg, S. Nahum, Ricke, Jens, Alunni-Fabbroni, Marianna |
| Předmět: |
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| Zdroj: |
Journal of Cancer Research & Clinical Oncology; Nov2023, Vol. 149 Issue 14, p13017-13026, 10p |
| Abstrakt: |
Purpose: The role of microRNA-146a (miR-146a) in defining the tumor immune microenvironment (TIME) is well established. The aim of this study was to evaluate circulating miR-146a as an early prognostic marker of 90Y-radioembolization (90Y-RE) in metastatic liver cancer and to assess the correlation between circulating miR-146a and TIME cellular composition in distant, yet untreated metastases. Methods: Twenty-one patients with bilobar liver lesions from gastro-intestinal cancer underwent lobar 90Y-RE. Biopsy of contralateral lobe abscopal tumors was acquired at the onset of a second treatment session at a median of 21 days after initial RE, immediately prior to ablation therapy of the contralateral lobe tumor. miR-146a was measured by RT-qPCR in plasma collected 24 h before (T1) and 48 h after (T2) initial unilobar 90Y-RE. The level of miR-146a was correlated with the infiltration of CD4 + , CD8 + , FoxP3 T cells, CD163 + M2 macrophages and immune-exhausted T cells in the abscopal tumor tissue acquired before the second treatment session. Results: Plasma samples collected at T2 showed a higher concentration of miR-146a with respect to T1 in 43% of the patients (p = 0.002). In these patients, tumors revealed a pro-tumorigenic immune composition with enrichment of Tim3 + immune exhausted cells (p = 0.021), in combination with a higher infiltration of CD163 + M2 macrophages and a lower infiltration of CD8 + T cells. Patients with a higher level of miR-146a after 90Y-RE showed a trend to shorter OS (p = 0.055). Conclusion: miR-146a may represent a novel prognostic biomarker for 90Y-radioembolization in metastatic liver cancer. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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