Clinical outcomes and antibody transfer in a cohort of infants with in utero or perinatal exposure to SARS-CoV-2 (Coronascope Study).

Autor: Carrasco Colom, Jaime, Manzanares, Ángela, Álvaro Gómez, Alicia, Serrano Escribano, Isabel, Esquivel, Estrella, Pérez-Rivilla, Alfredo, Moral-Pumarega, Maria Teresa, Aguirre Pascual, Elisa, De Vergas, Joaquín, Reda del Barrio, Sara, Moraleda, Cinta, Epalza, Cristina, Fernández-Cooke, Elisa, Prieto, Luis, Villaverde, Serena, Zamora, Berta, Herraiz, Ignacio, Galindo, Alberto, Folgueira, María Dolores, Delgado, Rafael
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Zdroj: European Journal of Pediatrics; Oct2023, Vol. 182 Issue 10, p4647-4654, 8p, 2 Charts
Abstrakt: We aimed to describe the outcomes, focusing on the hearing and neurological development, of infants born to mothers with COVID-19 during pregnancy and to evaluate the persistence of maternal antibodies in the first months of life. An observational, prospective study at a tertiary hospital in Madrid (Spain) on infants born to mothers with COVID-19 during pregnancy between March and September 2020 was conducted. A follow-up visit at 1–3 months of age with a physical and neurological examination, cranial ultrasound (cUS), SARS-CoV-2 RT-PCR on nasopharyngeal swab, and SARS-CoV-2 serology were performed. Hearing was evaluated at birth through the automated auditory brainstem response and at six months of age through the auditory steady-state response. A neurodevelopmental examination using the Bayley-III scale was performed at 12 months of age. Of 95 infants studied, neurological examination was normal in all of them at the follow-up visit, as was the cUS in 81/85 (95%) infants, with only mild abnormalities in four of them. Serology was positive in 47/95 (50%) infants, which was not associated with symptoms or severity of maternal infection. No hearing loss was detected, and neurodevelopment was normal in 96% of the infants (median Z score: 0). Conclusion: In this cohort, the majority of infants born to mothers with COVID-19 during pregnancy were healthy infants with a normal cUS, no hearing loss, and normal neurodevelopment in the first year of life. Only half of the infants had a positive serological result during the follow-up. What is Known: • Hearing loss and neurodevelopmental delay in infants born to mothers with COVID-19 during pregnancy has been suggested, although data is inconsistent. Maternal antibody transfer seems to be high, with a rapid decrease during the first weeks of life. What is New: • Most infants born to mothers with COVID-19 during pregnancy had normal hearing screening, cranial ultrasound, and neurodevelopmental status at 12 months of life. Antibodies against SARS-CoV-2 were only detected in 50% of the infants at two months of life. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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