Design and synthesis of novel 1,3-diene bridged chiral atropoisomeric diphosphine ligands for asymmetric hydrogenation of α-dehydro amino ketones.

Autor: Tan, Xuefeng, Gao, Shuang, Yang, Chunyan, Lang, Qiwei, Ding, Xiaobing, Chen, Gen-Qiang, Zhang, Xumu
Zdroj: SCIENCE CHINA Chemistry; Oct2023, Vol. 66 Issue 10, p2847-2851, 5p
Abstrakt: A series of novel atropisomeric diphosphine ligands termed TanPhos were designed and synthesized, which has a smaller bite angle compared with that of other ligands such as BINAP. TanPhos showed high reactivity and enantioselectivity in the rhodium-catalyzed asymmetric hydrogenation of a-dehydro amino ketones, and up 99% yield and 99% ee were obtained for a wide range of chiral α-amino ketones. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index