| Autor: |
Asami, M., Owhashi, M., Abe, T., Nawa, Y. |
| Předmět: |
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| Zdroj: |
Immunology & Cell Biology; Oct1991, Vol. 69 Issue 5, p355-360, 6p |
| Abstrakt: |
Summary The susceptibility of haemopoietic stem cell deficient W/Wvv mice to infection with Flusmodium berghei was examined. The mean survival time of W/Wv mice after the infection was shorter than that of the +/+ mice. Splenomegaly, a characteristic pathological change of the host after infection with malaria parasites was not observed in W/Wv mice. When haemopoietic activity of the infected mice was examined, a substantial increase in number of multipotent haemopoietic stem cells (CFU-S) and the committed stem cells for granulocytes and maerophages (CFU-GM) or for erythrocytes (CFU-E) was observed in the bone marrow and spleen of +/+ but not of W/Wv mice, CFU-S were not detected in W/Wv mice before or alter infection. The number of CFU-GM and CFU-E in bone marrow and spleen of W/Wv mice decreased after infection. Bone marrow grafting from +/ + to W/Wv mice 8 weeks before infection prolonged the mean survival time of the mice and effectively restored the number of CFU-S in the spleen of W/Wv mice. These results indicate that multipotent haemopoietic stem cells play an important role in the host's defence mechanisms against P. berghei-infection. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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