| Autor: |
Erdal, Huseyin, Ciftciler, Rafiye, Tuncer, Sibel Cigdem, Ozcan, Oguzhan |
| Předmět: |
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| Zdroj: |
Eurasian Journal of Medical Investigation; 2023, Vol. 7 Issue 4, p466-470, 5p |
| Abstrakt: |
Objectives: The present study aims to indicate both thiol-disulfide hemostasis and ischemia-modified albumin (IMA) levels in patients with Polycythemia Vera (PV). Methods: In this prospective case-control study, 34 PV patients and 31 healthy control participants were included. Thiol levels were measured with a new modified colorimetric method. IMA levels were determined by cobalt binding test. Results: Thiol levels were statistically significant between the groups. (p<0.001). IMA levels were also significanlty higher in PV group than healthy control subjects (p<0.001). We revealed that thiol and IMA levels were significantly higher in patients with PV in respect to the control groups. Conclusion: The obtain results indicate that the oxidative balance is disturbed and changed towards the oxidant direction. The dynamic- thiol disulfide balance has moved to proliferation side in patients with PV, and may provide important contributions to the patient's follow-up and disease pathophysiology. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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