Bridging thrombolysis improves survival rates at 90 days compared with direct mechanical thrombectomy alone in acute ischemic stroke due to basilar artery occlusion: a systematic review and meta- analysis of 1096 patients.

Autor:	Lee, Keng Siang, Siow, Isabel, Zhang, John JY, Syn, Nicholas, Gillespie, Conor S., Yuen, Linus ZH, Anil, Gopinathan, Yang, Cunli, Chan, Bernard PL, Sharma, Vijay Kumar, Teoh, Hock- Luen, Mingxue, Jing, Teo, Kevin Soon Hwee, Myint, May Zin, Bhogal, Pervinder, Meyer, Lukas
Předmět:	MEDICAL databases RELATIVE medical risk META-analysis MEDICAL information storage & retrieval systems CONFIDENCE intervals ISCHEMIC stroke SYSTEMATIC reviews INTRACRANIAL hemorrhage THROMBOLYTIC therapy BASILAR artery SURVIVAL rate TREATMENT effectiveness SUBARACHNOID hemorrhage MEDICAL emergencies MEDICAL protocols THROMBECTOMY DESCRIPTIVE statistics DISABILITIES MEDLINE ODDS ratio DATA analysis software CEREBRAL arteriosclerosis DISEASE complications
Zdroj:	Journal of NeuroInterventional Surgery; Oct2023, Vol. 15 Issue 10, p1039-1045, 7p
Abstrakt:	Background Mechanical thrombectomy (MT) is an effective treatment for patients with acute ischemic stroke (AIS) from basilar artery occlusion (BAO). Objective To compare the clinical outcomes of MT, with and without bridging intravenous thrombolysis (IVT), in acute BAO through a systematic review and meta- analysis of the current literature. Methods Systematic searches of Medline, EMBASE, and Cochrane Central were undertaken on August 1, 2022. Good functional outcome defined as 90- day modified Rankin Scale score 0--2 was the primary outcome measure. Secondary outcome measures were 90- day mortality, successful post- thrombectomy recanalization (modified Thrombolysis in Cerebral Infarction score ≥2b), symptomatic intracranial hemorrhage (sICH), and subarachnoid hemorrhage (SAH). Results Three studies reporting 1096 patients with BAO AIS were included in the meta- analysis. No significant differences in good functional outcome were detected between the two groups (RR=1.28 (95% CI 0.86 to 1.92); p=0.117). However, specifically patients with large artery atherosclerosis (LAA) benefited from bridging IVT (OR=2.52 (95% CI 1.51 to 4.22); p<0.001) with better functional outcomes. There was a significantly lower 90- day mortality rate for patients who underwent bridging IVT compared with MT alone (RR=0.70 (95% CI 0.62 to 0.80); p=0.008). No significant differences were detected in rates of post- treatment recanalization (RR=1.01 (95% CI 0.35 to 2.91); p=0.954), sICH (RR=0.96 (95% CI 0.66 to 1.42); p=0.724), and SAH (RR=0.93 (95% CI 0.31 to 2.83); p=0.563). Conclusions In patients with AIS due to BAO, bridging IVT was associated with lower mortality rates at 90 days, compared with direct MT. There were no improved functional outcomes or increased sICH or SAH between both arms, However, patients with LAA benefited from bridging IVT, with better functional outcomes. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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