One‐Pot Synthesis of β‐Ketoesters from Aryl Methyl Ketone via Ketene Dithioacetal.

Autor:	Giri, Nand Gopal, Althagafi, Ismail, Ghatak, Trisha, Pratap, Ramendra
Předmět:	METHYL ketones METHYLENE compounds ESTERS
Zdroj:	ChemistrySelect; 10/13/2023, Vol. 8 Issue 38, p1-7, 7p
Abstrakt:	We have discovered base‐mediated conversion of 3,3‐bis(methylthio)‐1‐arylprop‐2‐en‐1‐ones to versatile active methylene compounds (β‐keto esters). A series of products were isolated and characterized as a mixture of keto‐enol form. We have modified the method and synthesized the active methylene compounds (β‐keto esters) directly from aryl methyl ketone via ketene dithioacetal intermediate (not isolated) by stepwise reactions in one pot. Most of the one‐pot reactions also provided excellent yields. In addition to aryl methyl ketones, we also tested cyclopropyl methyl ketone as a source of an aliphatic ketone, and under similar reaction conditions, ethyl 3‐cyclopropyl‐3‐oxopropanoate was afforded. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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