| Abstrakt: |
Today, in addition to rodents, the non-human primates of the rhesus monkey (M. mulatta), which are valuable models in biomedical research, are at the disposal of scientists for experiments, in addition to rodents. Anatomical resemblance to humans makes it possible to successfully conduct studies of the digestive system, as well as to be used in preclinical and toxicological studies. In this regard, the study of white lupine in primates and its influence on their biochemical blood parameters, in order to extrapolate the results to humans, is an urgent task. In the present study, we established the effect of white lupine with an alkaloid content of 0.02% on the biochemical parameters of the blood of rhesus monkeys. We used the results of biochemical analysis of clinically healthy male M. mulatta at the age of 9 years and an average body weight of 10 kg. We studied both the main biochemical parameters (creatinine, urea, alkaline phosphatase, total protein, albumin, globulin, glucose and total bilirubin), and additional parameters (calcium and phosphorus concentration), the activity of a number of enzymes (ALT-Alanine aminotransferase, AST-spartate aminotransferase, GGT-Gamma-glutamyltransferase, LDH-lactate dehydrogenase), which are biochemical markers of damage to various systems and organs. The analysis of the research results as a result of the inclusion in the structure of the diet of white lupine with an alkaloidity of 0.02%, showed the absence of pathological abnormalities in the liver, heart muscle, skeletal muscles, pancreas and bile ducts. The studied indicators were within the reference values, which indicates a normal metabolism and the absence of inflammatory processes in the body. [ABSTRACT FROM AUTHOR] |
