Hydrothermal synthesis and characterization of nano-sized phosphors based on rare-earth activated yttrium compounds for photodynamic therapy.

Autor: Vlasenko, A. B., Dorokhina, A. M., Bakhmetyev, V. V., Khristyuk, N. A., Mjakin, S. V., Kuzina, E. N., Sychov, M. M., Kominami, H., Toru, A., Morii, H.
Zdroj: Journal of Sol-Gel Science & Technology; Nov2023, Vol. 108 Issue 2, p274-291, 18p
Abstrakt: Finely dispersed Y2O3:Eu, Y2Si2O7:Eu, YF3:Ce and YF3:Eu luminescent phosphors are synthesized using a hydrothermal method. A process is developed for obtaining Y2O3:Eu phosphors with a reduced particle size by hydrothermal precipitation with the addition of an inert finely dispersed filler (Aerosil) followed by rapid thermal annealing (RTA). Another process is suggested for the synthesis of finely dispersed Y2Si2O7:Eu phosphor via hydrothermal precipitation followed by microwave annealing. The effect of the synthesis conditions on the properties of YF3:Ce and YF3:Eu nanosized phosphors is studied and hydrothermal processing conditions were determined so as to provide the adjustment of their luminescence spectra due to the variation of the activator valency (Eu3+/Eu2+ and Ce3+/Ce2+). Besides earlier defined luminescence centers comprising Eu2+ ions in orthorhombic and cubic coordination positions of YF3 crystal lattice, the studied phosphors involve two additional types of luminescence centers relating to Eu(II), supposedly corresponding to Eu2+ in the same coordination positions located on the surface of the phosphor particles. Using the obtained data, an energy chart of Eu(II)-based luminescence centers in YF3:Eu nanosized phosphors is suggested. The resulting nanoscale particle size and luminescence spectra features of the synthesized phosphors YF3:Ce and YF3:Eu make them potentially useful for photodynamic therapy of cancer in combination with the photosensitizer Rose Bengal. The composition involving the synthesized Y2O3:Eu phosphor and photosensitizer Photoditazine was shown to provide an effective destruction of tumor cell cultures. Highlights: Y2O3:Eu nanosized phosphor is synthesized via hydrothermal precipitation followed by RTA. Finely dispersed Y2Si2O7:Eu is synthesized via hydrothermal precipitation with the addition of Aerosil followed by microwave annealing. An energy chart of Eu(II)-based luminescence centers in YF3:Eu nanosized phosphors is defined. Nanosized phosphors promising for the application in photodynamic therapy of cancer coupled with the photosensitizer Rose Bengal are obtained. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
Externí odkaz: