Association of periodontitis with cognitive decline and its progression: Contribution of blood‐based biomarkers of Alzheimer's disease to this relationship.

Autor:	Carballo, Álvaro, López‐Dequidt, Iria, Custodia, Antía, Botelho, João, Aramburu‐Núñez, Marta, Machado, Vanessa, Pías‐Peleteiro, Juan Manuel, Ouro, Alberto, Romaus‐Sanjurjo, Daniel, Vázquez‐Vázquez, Laura, Jiménez‐Martín, Isabel, Aguiar, Pablo, Rodríguez‐Yáñez, Manuel, Aldrey, José Manuel, Blanco, Juan, Castillo, José, Sobrino, Tomás, Leira, Yago
Předmět:	DISEASE progression BIOMARKERS HYPERTENSION ALZHEIMER'S disease CONFIDENCE intervals PERIODONTITIS TAU proteins REGRESSION analysis AMYLOID beta-protein precursor NEUROPSYCHOLOGICAL tests PSYCHOLOGICAL tests GENE expression AMBULATORY blood pressure monitoring DESCRIPTIVE statistics RESEARCH funding COGNITION disorders in old age LOGISTIC regression analysis SECONDARY analysis PROPORTIONAL hazards models DISEASE complications OLD age
Zdroj:	Journal of Clinical Periodontology; Nov2023, Vol. 50 Issue 11, p1444-1454, 11p
Abstrakt:	Aim: To assess whether periodontitis is associated with cognitive decline and its progression as well as with certain blood‐based markers of Alzheimer's disease. Materials and Methods: Data from a 2‐year follow‐up prospective cohort study (n = 101) was analysed. Participants with a previous history of hypertension and aged ≥60 years were included in the analysis. All of them received a full‐mouth periodontal examination and cognitive function assessments (Addenbrooke's Cognitive Examination (ACE) and Mini‐Mental State Examination [MMSE]). Plasma levels of amyloid beta (Aβ)1‐40, Aβ1‐42, phosphorylated and total Tau (p‐Tau and t‐Tau) were determined at baseline, 12 and 24 months. Results: Periodontitis was associated with poor cognitive performance (MMSE: β = −1.5 [0.6]) and progression of cognitive impairment (hazard ratio [HR] = 1.8; 95% confidence interval: 1.0–3.1). Subjects with periodontitis showed greater baseline levels of p‐Tau (1.6 [0.7] vs. 1.2 [0.2] pg/mL, p <.001) and Aβ1‐40 (242.1 [77.3] vs. 208.2 [73.8] pg/mL, p =.036) compared with those without periodontitis. Concentrations of the latter protein also increased over time only in the periodontitis group (p =.005). Conclusions: Periodontitis is associated with cognitive decline and its progression in elderly patients with a previous history of hypertension. Overexpression of p‐Tau and Aβ1‐40 may play a role in this association. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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