| Autor: |
Ayoub, Georges, Sinan, Hassan, Kourie, Hampig Raphael, Kattan, Joseph, Nasr, Fadi, Karak, Fadi el, Wakim, Jad, Ghosn, Marwan, Chahine, Georges, Farra, Chantal, Chebly, Alain |
| Zdroj: |
Future Oncology; Sep2023, Vol. 19 Issue 29, p1991-2002, 12p |
| Abstrakt: |
Aim: Chronic lymphocytic leukemia (CLL) is a highly heterogenous hemopathy. Genetic stratification of CLL patients has important prognostic and therapeutic values – mainly immunoglobulin heavy chain variable region gene (IGHV) mutational status and the presence of cytogenetic abnormalities. The genetics of CLL in Lebanon is scarcely described in the literature. Patients & methods: In this work, we studied the genetic biomarkers of 312 Lebanese CLL patients. Results: Prominent IGHV genes were IGHV4-34, IGHV1-69 and IGHV3-30; and CLL #1 and #5 presented major subsets. Some similarities as well as major differences were highlighted when comparing our data with previously published data. Conclusion: The distribution of IGHV alleles in our series differed from previously described distributions, suggesting involvement of antigenic selection and regional variables in CLL pathogenesis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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