| Autor: |
Andrade, Ana Raquel Colares de, Rezende, Mônica Dantas Sampaio, Portela, Fernando Victor Monteiro, Pereira, Livia Maria Galdino, Nascimento da Silva, Bruno, Lima-Neto, Reginaldo Gonçalves de, Rocha, Marcos Fábio Gadelha, Sidrim, José Júlio Costa, Castelo-Branco, Débora Souza Collares Maia, Cordeiro, Rossana de Aguiar |
| Předmět: |
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| Zdroj: |
Biofouling; Aug/Sep2023, Vol. 39 Issue 7, p719-729, 11p |
| Abstrakt: |
The present study aimed to: (1) evaluate the influence of the steroid hormones (SH) on biofilm development; (2) investigate the formation of persister cells (PC) in biofilms; and (3) investigate the influence of SH on PC formation. Biofilms were derived from vulvovaginal candidiasis (VVC) samples and evaluated by three models: microcosm biofilms grown in Vaginal Fluid Simulator Medium (MiB-VFSM); monospecies biofilms grown in VFSM (MoB-VFSM) and RPMI media (MoB-RPMI). SH altered cell counting and biomass of biofilms grown in VSFM; MoB-RPMI were negatively affected by SH. SH stimulated the formation of PC in MiB-VFSM but not MoB-VFSM; MoB-RPMI showed a lower number of PC in the presence of SH. The results showed that SH altered the dynamics of biofilm formation and development, depending on the study model. The data suggest the influence of hormones on the physiology of Candida biofilms and reinforce the importance of PC in the pathogenesis of VVC. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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