| Abstrakt: |
Despite advances in understanding the intricate pathophysiological mechanisms underlying peripheral nerve injury, there are still few proven cures. Finding potential alternative therapies is necessary because conventional therapies have associated side effects and poor efficacy. In this regard, a study was conducted that offered substitute therapeutic agents in place of the alloxan injection. The target study pathway after alloxan injection is oxidative stress and inflammatory pathways, according to the study point. It argues that multitarget therapies must be developed to combat inflammation brought on by diabetic complications. Alloxan (150 mg/kg) was injected intraperitoneally to cause diabetes in the DC group. The treatment with ashwagandha root extract (100 and 200 mg/kg/day) began 6 weeks after the diabetes was induced and lasted for 6 weeks in total. After the treatment, behavioral tests known as the hot plate test (HBT) and narrow beam test (NBT) were conducted. Glucose and creatine phosphokinase (CPK) levels in the blood, as well as oxidative, antioxidant, and pro-inflammatory cytokines, were measured. Histological analysis of the pancreas and sciatic nerve was conducted. Response times to thermal pain during HPT were significantly faster under ashwagandha root extract treatments. The total time required to cross the beam during NBT significantly decreased in both the treated diabetic groups with ashwagandha extract. About glucose level, CPK, oxidative stress biomarkers, and pro-inflammatory cytokines, the treatment group receiving ashwagandha root extract attenuated the changes brought on by diabetes. Histological examination revealed that the pancreas damage caused by diabetic animals and the altered infiltration of inflammatory cells in the sciatic nerve were both reversed by ashwagandha root extract. As a result of our research, ashwagandha root extract, which is rich in phenolic compounds, may help with traditional therapeutic agents for the treatment of inflammation brought on by diabetic complications. [ABSTRACT FROM AUTHOR] |
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