| Abstrakt: |
B (1 b B I R i b B ,5 b B I S i b B )-3-(2-Bromoethyl)-11-chloro-3,4,5,6-tetrahydro-1 b B I H i b B -1,5-methanopyrido[1,2- b B I a i b B ][1,5]diazocin-8(2 b B I H i b B )-one (13) and (1 b B I R i b B ,1 b ' B I R i b B ,5 b B I S i b B ,5 b ' B I S i b B )-3,3 b ' B -(ethane-1,2-diyl)bis(11-chloro-3,4,5,6-tetrahydro-1 b B I H i b B -1,5-methanopyrido[1,2- b B I a i b B ][1,5]diazocin-8(2 b B I H i b B )-one (14) b were prepared from 11-chlorocytisine ( B 5 b ) by I method A i for B 7 b and B 8 b to afford B 13 b (0.091 g, 33%) and B 14 b (0.081 g, 38%). B (1 b B I R i b B ,5 b B I S i b B )-3-(2-Bromoethyl)-9,11-dichloro-3,4,5,6-tetrahydro-1 b B I H i b B -1,5-methanopyrido[1,2- b B I a i b B ][1,5]diazocin-8(2 b B I H i b B )-one (15) and (1 b B I R i b B ,1 b ' B I R i b B ,5 b B I S i b B ,5 b ' B I S i b B )-3,3 b ' B -(ethane-1,2-diyl)bis(9,11-dichloro-3,4,5,6-tetrahydro-1 b B I H i b B -1,5-methanopyrido[1,2- b B I a i b B ][1,5]diazocin-8(2 b B I H i b B )-one (16) b were prepared from 9,11-dichlorocytisine ( B 6 b ) by I method A i for B 7 b and B 8 b to afford B 15 b (0.11 g, 39%) and B 16 b (0.083 g, 39%). Chemical transformations of natural compounds are traditionally used to seek and design new biologically active compounds, including those with antitumor activity. [Extracted from the article] |
