| Autor: |
Berrones Reyes, Jessica, Sherin, Peter S., Sarkar, Amrita, Kuimova, Marina K., Vilar, Ramon |
| Předmět: |
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| Zdroj: |
Angewandte Chemie International Edition; 10/16/2023, Vol. 62 Issue 42, p1-9, 9p |
| Abstrakt: |
G‐quadruplex DNA is a non‐canonical structure that forms in guanine‐rich regions of the genome. There is increasing evidence showing that G‐quadruplexes have important biological functions, and therefore molecular tools to visualise these structures are important. Herein we report on a series of new cyclometallated platinum(II) complexes which, upon binding to G‐quadruplex DNA, display an increase in their phosphorescence, acting as switch‐on probes. More importantly, upon binding to G‐quadruplexes they display a selective and distinct lengthening of their emission lifetime. We show that this effect can be used to selectively visualise these structures in cells using Phosphorescence Lifetime Imaging Microscopy (PLIM). [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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