| Autor: |
Papageorgiou, Theocharis C., Guibert, Juliette, Savale, Michèle, Goffinet, François, Fournier, Charles, Merlet, Françoise, Janssens, Yvette, Zorn, Jean-René |
| Předmět: |
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| Zdroj: |
BJOG: An International Journal of Obstetrics & Gynaecology; Nov2004, Vol. 111 Issue 11, p1277-1282, 6p, 2 Charts, 3 Graphs |
| Abstrakt: |
To evaluate the rate of multiple pregnancies in intrauterine insemination cycles stimulated with a minimal dose of recombinant follicle stimulating hormone (rec-FSH).Retrospective study.University Medical Center.A total of 1256 patients underwent 3219 consequent intrauterine insemination cycles with minimal ovarian stimulation.Patients received 50 or 75 IU of rec-FSH from day four to day seven. The dose was adjusted according to oestradiol (E2) levels in order to achieve a maximum of two follicles on the day of hCG administration.Peak E2 levels, the number of follicles>15 mm and pregnancy rates were calculated. The predictive value of E2 levels for multiple gestations was also estimated.Of 3219 cycles, 334 resulted in pregnancies (10%). Of these, 238 (91%) were singletons, 28 (8%) twins and 1 (0.3%) was a triplet. The cumulative overall pregnancy rate was 43%. Patients over 40 years old had a significantly lower pregnancy rate per cycle and overall live birth rate (P<0.05). Most pregnancies (83%) occurred during the first three cycles. Pregnancy rates per cycle varied from 8% for tubal factor to 14% for anovulation infertility.Minimal FSH stimulation in intrauterine insemination cycles may reduce the rates of twins and high order multiple pregnancies without affecting overall pregnancy rates. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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