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WS2 IS THE CURRENT HLA-A-B-DR MISMATCH FORMULAR AN ADEQUATE TOOL IN ORDER TO INDICATE POTENTIAL H... Carolina Ruiz Bucksch 1, Anastasia Doroshenko 1, Gerald Schlaf 1 1 Universitätsklinikum Halle, Halle (Saale), Germany B Correspondence: b gerald.schlaf@uk-halle.de The HLA-A-B-DR mismatch (MM-) formular, which only comprises the phenotypes of HLA-class I gene loci A and B and that of HLA-class II gene locus DR (DRB1) has for years been used in order to define the HLA-compatibility of organ donors and their chosen recipients. WS6 A STRATEGY IN ORDER TO CIRCUMVENT FALSE-NEGATIVE RESULTS OF LUMINEX-BASED ANTI-HLA ANTIBODY S... Anja Wahle 1, Anastasia Doroshenko 1, Wolfgang Altermann 1, Gerald Schlaf 1 1 HLA-Laboratory, Halle (Saale), Germany B Correspondence: b gerald.schlaf@uk-halle.de Early CDC-based cell tray analyses for anti-HLA antibody detection/specification were always characterized by low sensitivities and limited levels of resolution. Recipient and donor HLA typing, pre- and post-transplant HLA antibody status and clinical data for statistical analysis were available for 87 patients - 77 first-time transplant recipients and 10 patients after re-transplantation. This principle of the reduced consideration of HLA is due to the so-called linkage disequilibrium, that is, two genetically closely coupled HLA class I loci HLA-B with HLA-C on the one, and of HLA class II loci HLA-DRB1 with HLA-DRB3/4/5 and with HLA-DQB1 on the other hand. [Extracted from the article] |
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