Emerging roles for G‐quadruplexes in proteostasis.

Autor:	Guzman, Bryan B., Son, Ahyun, Litberg, Theodore J., Huang, Zijue, Dominguez, Daniel, Horowitz, Scott
Předmět:	QUADRUPLEX nucleic acids NUCLEIC acids PROTEIN folding PHASE separation DNA structure PROTEOLYSIS
Zdroj:	FEBS Journal; Oct2023, Vol. 290 Issue 19, p4614-4625, 12p
Abstrakt:	How nucleic acids interact with proteins, and how they affect protein folding, aggregation, and misfolding is a still‐evolving area of research. Considerable effort is now focusing on a particular structure of RNA and DNA, G‐quadruplexes, and their role in protein homeostasis and disease. In this state‐of‐the‐art review, we track recent reports on how G‐quadruplexes influence protein aggregation, proteolysis, phase separation, and protein misfolding diseases, and pose currently unanswered questions in the advance of this scientific field. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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