| Abstrakt: |
Predictive factors for rectal cancer Y. Aliyarov* National Oncology Centre of Azerbaijan Republic, Baku, Azerbaijan B Aim: b To investigate the role of mutation in KRAS and BRAF genes as predictive marker of radioresistanse in patients with local advanced rectal cancer undergoing neoadjuvant radiochemotherapy. Twenty-four patients received optimisation before elective surgery, and thirty patients received emergency surgery, without optimisation. All patients with symptomatic AL and PD underwent surgery as a treatment for leak, whereas patients with symptomatic AL and without PD were treated with surgery (66.7%), endoscopic (19.0%) and percutaneous (14.3%) procedures. 15.9% (30 patients) of the patients had tumour out of rectosigmoid colon (7 patients transverse/6 patients ascending/17 patients descending) and 84.1% (158 patients). Among clinical groups the distribution of patients with KRAS mutation was: 1 group- 6 (37.5%) patients, 2 group- 8 (23.5%) patients, 3 group -3 (20%) patients ( I p i < 0.5). [Extracted from the article] |
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