Assessment of antibody titer and side effects after fourth doses of COVID-19 mRNA vaccination in 38 healthy volunteers.
| Autor: | Kozakai, Rikei, Suzuki, Susumu, Sato, Yuri, Takahashi, Mizue, Chida, Nodoka, Takahashi, Mei, Hoshi, Kuniko, Takahashi, Shinichiro |
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STATISTICS
SICK leave IMMUNOGLOBULINS PAIN ACADEMIC medical centers FEVER MYALGIA NAUSEA DIARRHEA COVID-19 vaccines CHEMILUMINESCENCE assay AGE distribution DIZZINESS INFLAMMATION CONSTIPATION URINATION disorders HEALTH status indicators REGRESSION analysis EXANTHEMA JOINT pain MUSCLE weakness LYMPHATIC diseases ANTIBODY formation VOMITING RHINORRHEA DYSPNEA MESSENGER RNA DESCRIPTIVE statistics MENTAL depression NUMBNESS CHEST pain COUGH RESEARCH funding VIRAL antibodies FATIGUE (Physiology) DATA analysis software DATA analysis HEADACHE ABDOMINAL pain HEARTBURN ANXIETY PSYCHOLOGICAL stress MANIA VERTIGO PHARYNGITIS |
| Zdroj: | Journal of Laboratory Medicine; Oct2023, Vol. 47 Issue 5, p199-209, 11p |
| Abstrakt: | Fourth dose of SARS-CoV-2 vaccination was started from the end of May, 2022 in Japan. However, data on the precise analysis of the side effects after fourth vaccination, remain scarce. Here, we examined the side effects and the levels of SARS-CoV-2 antibody titers in healthy volunteers who underwent BNT162b2 vaccination for the fourth time. Thirty-eight volunteers were assessed for the side effects of the vaccination for the fourth dose, and samples were used for the measurement of SARS-CoV-2 IgG and IgM antibody with chemiluminescent assays. We found that the level of IgG at day 504 (average, 117.9 AU/mL [SD 76.9]), was significantly higher than at day 264 (average, 17.3 AU/mL [SD 13.1]), which are 8 months after the third and second vaccination, respectively. The level of IgG was potently increased after fourth vaccination (average, 711.8 AU/mL [SD 361.9]), whereas IgM remained baseline level. Commonly reported side effects in the participants after the fourth dose were similar to those until third dose, such as sore arm/pain (81.0 %), generalized weakness/fatigue (57.1 %) and fever (54.8 %). The number of side effects were significantly decreased with age, and participant with sore arm/pain had higher IgG titer (p=0.0007), whereas participant with lymphadenopathy had lower IgG (p=0.0371). The level of IgG was significantly higher in 8 months after the third, compared to the second, vaccination, and it was potently increased after fourth vaccination. The number of side effects were inversely correlated with age. Sore arm/pain and lymphadenopathy may affect IgG titer. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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