Enhanced IL-17 Producing and Maintained Cytolytic Effector Functions of Gut Mucosal CD161 + CD8 + T Cells in SIV-Infected Rhesus Macaques.

Autor: Thirugnanam, Siva, Walker, Edith M., Schiro, Faith, Aye, Pyone P., Rappaport, Jay, Rout, Namita
Předmět:
Zdroj: Viruses (1999-4915); Sep2023, Vol. 15 Issue 9, p1944, 14p
Abstrakt: Previous studies have indicated that the loss of CD161-expressing CD4+ Th17 cells is linked to the progression of chronic HIV. These cells are significantly depleted in peripheral blood and gut mucosa of HIV-infected individuals, contributing to inflammation and disruption of the gut barrier. However, the impact of HIV infection on CD161-expressing CD8+ T cells remain unclear. Here, we examined the functions of peripheral blood and mucosal CD161+CD8+ T cells in the macaque model of HIV infection. In contrast to the significant loss of CD161+CD4+ T cells, CD161+CD8+ T cell frequencies were maintained in blood and gut during chronic SIV infection. Furthermore, gut CD161+CD8+ T cells displayed greater IL-17 production and maintained Th1-type and cytolytic functions, contrary to impaired IL-17 and granzyme-B production in CD161+CD4+ T cells of SIV-infected macaques. These results suggest that augmented Th17-type effector functions of CD161+CD8+ T cells during SIV infection is a likely mechanism to compensate for the sustained loss of gut mucosal Th17 cells. Targeting the cytokine and cytolytic effector functions of CD161+CD8+ T cells in the preclinical setting of chronic SIV infection with antiretroviral therapy has implications in the restoration of gut barrier disruption in persons with HIV infection. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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