| Autor: |
van der Woude, F. J., van der Giessen, M., Kallenberg, C. G. M., Ouwehand, W., Beekhuis, H., Beelen, J. M., van Son, W. J., Hoedemaeker, J., van der Hem, G. K., The, T. H. |
| Předmět: |
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| Zdroj: |
Clinical & Experimental Immunology; Mar1984, Vol. 55 Issue 3, p473-480, 8p |
| Abstrakt: |
Reticuloendothelial system (RES) Fc receptor-mediated immune clearance was measured in 18 patients with systemic lupus erythematosus (SLE). Only two patients, with major disease activity, had a prolonged T½ of the blood disappearance curve of injected IgG coated red cells in comparison to 22 healthy controls. Circulating immune complexes (CIC) were studied with three methods: PEG precipitation, Clq-ELISA and the indirect granulocyte phagocytosis test (IGFT). The T½ of the blood disappearance curve related significantly to the IGFT (r=0.55, P <0.05) and not to the PEG and Clq-ELISA test. Although HLA-DR3 phenotype frequency was significantly increased in our SLE population (P < 0.05), it was not related to Fc receptor function. Similarly, HLA-DR2 phenotype was not related to RES Fc receptor function. These data do not support the concept that a genetic HLA linked defect in reticuloendothelial Fc receptor function is a primary cause of SLE, predisposing the inflicted individual to immune complex deposition. However, Fc receptor-mediated immune clearance seems to be related to disease activity itself and to levels of CIC. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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