Multi-omics reveal neuroprotection of Acer truncatum Bunge Seed extract on hypoxic-ischemia encephalopathy rats under high-altitude.

Autor: Chen, Xianyang, Song, Yige, Song, Wangting, Han, Jiarui, Cao, Hongli, Xu, Xiao, Li, Shujia, Fu, Yanmin, Ding, Chunguang, Lin, Feng, Shi, Yuan, Li, Jiujun
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Zdroj: Communications Biology; 10/2/2023, Vol. 6 Issue 1, p1-13, 13p
Abstrakt: Hypoxic-ischemic encephalopathy (HIE) at high-altitudes leads to neonatal mortality and long-term neurological complications without effective treatment. Acer truncatum Bunge Seed extract (ASO) is reported to have effect on cognitive improvement, but its molecular mechanisms on HIE are unclear. In this study, ASO administration contributed to reduced neuronal cell edema and improved motor ability in HIE rats at a simulated 4500-meter altitude. Transcriptomics and WGCNA analysis showed genes associated with lipid biosynthesis, redox homeostasis, neuronal growth, and synaptic plasticity regulated in the ASO group. Targeted and untargeted-lipidomics revealed decreased free fatty acids and increased phospholipids with favorable ω-3/ω-6/ω-9 fatty acid ratios, as well as reduced oxidized glycerophospholipids (OxGPs) in the ASO group. Combining multi-omics analysis demonstrated FA to FA-CoA, phospholipids metabolism, and lipid peroxidation were regulated by ASO treatment. Our results illuminated preliminary metabolism mechanism of ASO ingesting in rats, implying ASO administration as potential intervention strategy for HIE under high-altitude. Acer truncatum Bunge Seed extract (ASO) can potentially alleviate brain injuries in neonates affected by hypoxic-ischemic encephalopathy exposed to high-altitude conditions by protecting the nervous system and improving motor and cognitive abilities. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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