Synthesis, Physicochemical Properties, and Antimicrobial Activity of Polymyxin B1 Conjugates with Polyglutaraldehyde.

Autor:	Shalygina, V. V., Vlasova, E. N., Anan'eva, E. P., Gaidukova, V. A.
Předmět:	ANTI-infective agents POLYMYXIN GLUTARALDEHYDE GRAM-positive bacteria CONJUGATED polymers GRAM-negative bacteria POLYMER structure
Zdroj:	Pharmaceutical Chemistry Journal; May2019, Vol. 53 Issue 2, p134-138, 5p
Abstrakt:	Polymyxin B1 conjugates with polyglutaraldehyde were synthesized using reductive amination. The synthesized polymeric antibiotic derivatives were tested for antimicrobial activity against Gram-negative and Gram-positive bacteria. Polymyxin B1 was found to be stable under the reaction conditions. The main structural factors influencing the antimicrobial activity of these conjugates were the composition and structure of the polyglutaraldehyde polymer chain. The polymer-antibiotic conjugates were very soluble in aqueous solutions and organic solvents. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
Externí odkaz:	Zobrazit plný text záznamu Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.