Catecholamines Promote Ovarian Cancer Progression through Secretion of CXC-Chemokines.

Autor:	Kim, Hyun Jung, Chang, Ha Kyun, Lee, Yul Min, Heo, Kyun
Předmět:	OVARIAN cancer CANCER invasiveness CATECHOLAMINES SECRETION PSYCHOLOGICAL stress NEOVASCULARIZATION ADRENALINE
Zdroj:	International Journal of Molecular Sciences; Sep2023, Vol. 24 Issue 18, p14104, 13p
Abstrakt:	Considerable evidence has accumulated in the last decade supporting the notion that chronic stress is closely related to the growth, metastasis, and angiogenesis of ovarian cancer. In this study, we analyzed the conditioned media in SKOV3 ovarian cancer cell lines treated with catecholamines to identify secreted proteins responding to chronic stress. Here, we observed that epinephrine and norepinephrine enhanced the secretion and mRNA expression of CXC-chemokines (CXCL1, 2, 3, and 8). Neutralizing antibodies to CXCL8 and CXCL8 receptor (CXCR2) inhibitors significantly reduced catecholamine-mediated invasion of SKOV3 cells. Finally, we found that the concentration of CXCL1 and CXCL8 in the plasma of ovarian cancer patients increased with stage progression. Taken together, these findings suggest that stress-related catecholamines may influence ovarian cancer progression through the secretion of CXC-chemokines. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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