Incorporation of doxylamine and N‐doxylamine‐oxide in human hair and the impact of a permanent oxidative hair dye.

Autor: Ramirez Fernandez, Maria del Mar, Wille, Sarah M. R., Samyn, Nele
Zdroj: Drug Testing & Analysis; Sep2023, Vol. 15 Issue 9, p933-940, 8p
Abstrakt: Knowledge of the drug incorporation in hair and impact of cosmetic treatments remains essential to correctly interpret forensic cases. The study shows the analysis of doxylamine and doxylamine‐N‐oxide and the evaluation of the relationship between dose and hair concentration and the impact of hair treatment (oxidative dying). The study included (A) three subjects participated to the study: a regular user (Subject 1) and two single‐dose users (Subject 2, 1 single dose; and Subject 3, 2 single doses spaced 5 months apart). Subject 3 applied a permanent oxidative hair dying monthly. (B) A permanent oxidative hair dying was applied twice to the hair collected from Subject 2. (A) The average concentrations in head hair for doxylamine and its N‐doxylamine‐oxide, respectively, were as follows: Subject 1, 1825 pg/mg and 16 pg/mg; Subject 2, 182 and
Databáze: Complementary Index