| Autor: |
Khan, Islam, Omu, Alexander E., Fatinikun, Tunde, Chandrasekhar, Bindu, Kadavil, Elizabeth A., Oriowo, Mabayoje A. |
| Předmět: |
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| Zdroj: |
Pharmacology; 2005, Vol. 74 Issue 3, p157-162, 6p |
| Abstrakt: |
β1- and β2-adrenoceptors mediate relaxation in the oviductal smooth muscle. This study examines the existence and function of β3-adrenoceptors in the human oviduct. Ring segments of the oviduct were set up for isometric tension recording. The effect of isoprenaline and BRL 37344 on smooth muscle tone was examined. The expression of β3-adrenoceptors in the oviduct was also examined. Isoprenaline and BRL 37344 concentration-dependently relaxed circular muscles of the oviduct. BRL 37344 was less potent than isoprenaline and was a partial agonist. Propranolol shifted isoprenaline but not BRL 37344 concentration-response curve to the right without reducing the maximum response. Cyanopindolol (1 μmol/l), a β3-adrenoceptor antagonist, shifted the isoprenaline concentration response curve to the right. The –log KB value of 7.8 indicates activation of β3-adrenoceptors by isoprenaline. mRNA for β3-adrenoceptors was expressed in the oviduct. These results suggest that β3-adrenoceptors, mediating relaxation, are expressed in the human oviduct. Copyright © 2005 S. Karger AG, Basel [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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