Chitosan Sponges for Efficient Accumulation and Controlled Release of C-Phycocyanin.

Autor: Sergeeva, Yana E., Zakharevich, Anastasia A., Sukhinov, Daniil V., Koshkalda, Alexandra I., Kryukova, Mariya V., Malakhov, Sergey N., Antipova, Christina G., Klein, Olga I., Gotovtsev, Pavel M., Grigoriev, Timofei E.
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Zdroj: BioTech; Sep2023, Vol. 12 Issue 3, p55, 14p
Abstrakt: The paper proposed a new porous material for wound healing based on chitosan and C-phycocyanin (C-PC). In this work, C-PC was extracted from the cyanobacteria Arthrospira platensis biomass and purified through ammonium sulfate precipitation. The obtained C-PC with a purity index (PI) of 3.36 ± 0.24 was loaded into a chitosan sponge from aqueous solutions of various concentrations (250, 500, and 1000 mg/L). According to the FTIR study, chitosan did not form new bonds with C-PC, but acted as a carrier. The encapsulation efficiency value exceeded 90%, and the maximum loading capacity was 172.67 ± 0.47 mg/g. The release of C-PC from the polymer matrix into the saline medium was estimated, and it was found 50% of C-PC was released in the first hour and the maximum concentration was reached in 5–7 h after the sponge immersion. The PI of the released C-PC was 3.79 and 4.43 depending on the concentration of the initial solution. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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