Synthesis of Quinoline and Quinolin-2(1 H)-one Derivatives via Nickel Boride Promoted Reductive Cyclization.

Autor:	Sarkar, Rumpa, Samanta, Surya Kanta, Menon, Anila M., Chopra, Deepak, Ganguly, Debabani, Bera, Mrinal K.
Předmět:	QUINOLINE derivatives QUINOLINE ACRYLATES RING formation (Chemistry) BORIDES ETHYL acetoacetate NICKEL AMINATION ANILINE derivatives
Zdroj:	Synthesis; Oct2023, Vol. 55 Issue 20, p3303-3314, 12p
Abstrakt:	[13] The early syntheses of quinoline derivatives, such as the Friedländer, [39][40] Skraup, [41] Doebner, [42] Combes, [43] Conrad-Limpach, [44][45] and Povarov [46][47] synthesis, generally relied on aniline or aniline derivatives as starting materials along with diverse annulation partners. To demonstrate the practical usefulness of our synthetic molecules, we selected quinoline derivative B 5m b to assemble a quinoline-fused pyrrolidin-2-one derivative (Scheme 3). Keywords: quinolines; quinolin-2(1 H)-ones; nickel boride; sodium borohydride; reductive cyclization EN quinolines quinolin-2(1 H)-ones nickel boride sodium borohydride reductive cyclization 3303 3314 12 09/29/23 20231018 NES 231018 Graph Nitrogen heteroaromatics continue to play a pivotal role in modern drug design and discovery. [Extracted from the article]
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