| Autor: |
Yang, Shuai, Shen, Wen, Zhang, Hong-Zhou, Wang, Chen-Xi, Yang, Ping-Ping, Wu, Qing-Hua |
| Zdroj: |
Cardiovascular Drugs & Therapy; Oct2023, Vol. 37 Issue 5, p927-940, 14p |
| Abstrakt: |
Background: Patients at high cardiovascular risk are closely associated with an increased risk of atrial fibrillation (AF). Whether proprotein convertase subtilisin/kexin type 9 monoclonal antibodies (PCSK9 mAbs) can attenuate AF progression remains unknown. Methods: To compare PCSK9 mAbs with placebo or ezetimibe to explore the effect of PCSK9 mAbs therapy on the end-point of incidence of AF, we searched PubMed, Embase, and ClinicalTrials.gov for articles. We used Mantel–Haenszel risk ratio (RR) with corresponding 95% CI for the categorical data, including the incidence of AF and predefined other outcomes of interest. Results: We included 21 articles consisting of 26 randomized controlled trials with a total of 95,635 participants. Quantitative synthesis revealed that PCSK9 mAbs significantly reduce the incidence of AF events (RR 0.84; 95% CI 0.72−0.98; p = 0.03), whereas no obvious differences were seen between the PCSK9 mAbs group and the ezetimibe group (RR 0.90; 95% CI 0.29–2.76; p = 0.85). PCSK9 mAbs also markedly decreased the incidence of cerebrovascular events (RR 0.75; 95% CI 0.66−0.85; p < 0.0001) and new-onset hypertension (RR 0.92; 95% CI 0.87–0.97; p = 0.003), but not the risk of cardiovascular death (RR 0.95; 95% CI 0.85–1.07; p = 0.40) and new-onset diabetes mellitus (RR 1.01; 95% CI 0.95–1.08; p = 0.67). Conclusions: Overall, the PCSK9 mAbs therapy reduced AF and presented certain cardiovascular benefits in patients at high cardiovascular risk. Further big-scale and long follow-up duration randomized controlled trials that compare PCSK9 mAbs with ezetimibe are required to evaluate the effect of PCSK9 mAbs versus ezetimibe on AF. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
Full text from SpringerLink