Cytotoxic Activity of A-Modified Licorice Triterpenoid Derivatives.

Autor:	Baltina, L. A., Khusnutdinova, N. S., Karimova, E. R., Saifullina, D. R., Kondratenko, R. M.
Předmět:	ACID derivatives CELL lines CANCER cells PYRAZOLES NEUROBLASTOMA
Zdroj:	Pharmaceutical Chemistry Journal; Aug2023, Vol. 57 Issue 5, p637-641, 5p
Abstrakt:	The cytotoxic activity of a number of A-modified derivatives of glycyrrhetic acid (GLA) and 11-deoxo- and 18,19-dehydro-GLA against conditionally normal HEK 293 cells, A549 human lung carcinoma, MCF-7 breast adenocarcinoma, and SH-SY5Y neuroblastoma cells was studied. The most active compound was 18,19-dehydro-GLA methyl ester with a pyrazole fragment, which exhibited a pronounced cytotoxic effect against A549, MCF-7, and SH-SY5Y cancer cell lines (IC50 22.57 – 38.11 μM). [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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