| Autor: |
Auerswald, Heidi, Maestri, Alvino, Touch, Sothy, In, Saraden, Ya, Nisa, Heng, Borita, Bosch-Castells, Valérie, Augard, Christele, Petit, Céline, Dussart, Philippe, Peng, Yiksing, Cantaert, Tineke, Ly, Sowath |
| Předmět: |
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| Zdroj: |
Clinical Infectious Diseases; Sep2023, Vol. 77 Issue 6, p910-916, 7p |
| Abstrakt: |
All World Health Organization (WHO) pre-qualified rabies vaccines for humans are inactivated tissue culture rabies virus formulations produced for intramuscular (IM) administration. Due to costs and vaccine shortage, dose-saving intradermal (ID) administration of rabies post-exposure prophylaxis (PEP) is encouraged by WHO. This study compared the immunogenicity of the ID 2-site, 3-visit Institut Pasteur Cambodge (IPC) PEP regimen to the IM 1-site, 4-visit 4-dose Essen regimen using Verorab vaccine (Sanofi). The development of neutralizing antibodies (nAbs) and T cell response was assessed in 210 patients with a category II or III animal exposure in a rabies-endemic country. At day 28, all participants developed nAbs (≥0.5 IU/mL), irrespective of PEP scheme, age, or administration of rabies immunoglobulin. T cell response and nAb titers were similar for both PEP schemes. This study demonstrated that the 1-week ID IPC regimen is as effective as the 2-week IM 4-dose Essen regimen in inducing an anti-rabies immune response under real-life PEP. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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