| Autor: |
Fernández-Bertólez, Natalia, Touzani, Assia, Martínez, Luisa, Méndez, Josefina, Reis, Ana Teresa, Costa, Carla, Fraga, Sonia, Teixeira, João Paulo, Pásaro, Eduardo, Laffon, Blanca, Valdiglesias, Vanessa |
| Předmět: |
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| Zdroj: |
Materials Proceedings; 2023, Vol. 14, p4, 6p |
| Abstrakt: |
Cerium dioxide nanoparticles (CeO2NP) show antioxidant enzyme-like properties and reactive oxygen species (ROS) scavenging activity, making them a promising material for potential therapeutic applications in neurodegenerative diseases. The objective of this work was to assess the biological behavior of CeO2NP in human SH-SY5Y neuronal and A172 glial cells by means of the MTT assay and the γH2AX assay. Despite the significant dose- and time-dependent NP internalization by both cell lines, nanoceria generally presented scarce cytotoxicity or genotoxicity, essentially restricted to the highest NP doses and longest exposure times. In conclusion, a high biocompatibility of CeO2NP was observed under the conditions tested. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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