Inhibitory effect of O-propargyllawsone in A549 lung adenocarcinoma cells.
| Autor: | dos Santos, Edmilson Willian Propheta, de Sousa, Rauan Cruz, de Franca, Mariana Nobre Farias, Santos, Jileno Ferreira, Ottoni, Flaviano Melo, Isidório, Raquel Geralda, de Lucca Junior, Waldecy, Alves, Ricardo José, Scher, Ricardo, Corrêa, Cristiane Bani |
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| Předmět: |
PHYTOTHERAPY
THERAPEUTIC use of antineoplastic agents ADENOCARCINOMA LUNG cancer QUINONE WOUND healing FLOW cytometry STAINS & staining (Microscopy) ANALYSIS of variance COLONY-forming units assay HEMOLYSIS & hemolysins ANTINEOPLASTIC agents APOPTOSIS CELL motility LEAVES CELL lines PLANT extracts MOLECULAR structure ERYTHROCYTES DATA analysis software NECROSIS CELL death PHARMACODYNAMICS |
| Zdroj: | BMC Complementary Medicine & Therapies; 9/20/2023, Vol. 23 Issue 1, p1-13, 13p, 3 Color Photographs, 1 Diagram, 1 Chart, 3 Graphs |
| Abstrakt: | Background: Lung cancer is the deadliest type of cancer in the world and the search for compounds that can treat this disease is highly important. Lawsone (2-hydroxy-1,4-naphtoquinone) is a naphthoquinone found in plants from the Lawsone genus that show a high cytotoxic effect in cancer cell lines and its derivatives show an even higher cytotoxic effect. Methods: Sulforhodamine B was used to evaluate the cytotoxic activity of compounds on tumor cells. Clonogenic assay was used to analyze the reduction of colonies and wound healing assay to the migratory capacity of A549 cells. Apoptosis and necrosis were analyzed by flow cytometer and Giemsa staining. Hemolysis assay to determine toxicity in human erythrocytes. Results: Lawsone derivatives were evaluated and compound 1 (O-propargyllawsone) was the one with the highest cytotoxic effect, with IC |
| Databáze: | Complementary Index |
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