Three separate acquisitions of blaNDM-1 in three different bacterial species from a single patient.

Autor:	Mataseje, L. F., Pitout, J., Croxen, M., Mulvey, M. R., Dingle, T. C.
Předmět:	WHOLE genome sequencing PSEUDOMONAS aeruginosa SPECIES ENTEROBACTERIACEAE
Zdroj:	European Journal of Clinical Microbiology & Infectious Diseases; Oct2023, Vol. 42 Issue 10, p1275-1280, 6p
Abstrakt:	To investigate the acquisition and relatedness of New Delhi Metallo-beta-lactamase among multiple separate species from one patient. Five isolates from three species (Pseudomonas aeruginosa; Pa, Acinetobacter baumannii; Ab and Proteus mirabilis; Pm) suspected of harbouring a carbapenemase were investigated by phenotype (antimicrobial susceptibilities) and whole genome sequencing. Epidemiological data was collected on this patient. Three different carbapenemase genes were detected; blaVIM-1 (Pa; ST773), blaOXA-23 (Ab, ST499) and blaNDM-1 identified in all isolates. NDM regions were found chromosomally integrated in all isolates. Data showed no evidence of NDM-1 transfer within this patient suggesting the enzyme was acquired in three separate events. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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