Early application of continuous positive airway pressure in COVID-19 patients at risk of obstructive sleep apnea.

Autor: Emad, Zeinab, Ibrahim, Mohammed A., Abdelgawad, TahaTaha, Saleh, Abdelbaset M.
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Zdroj: Egyptian Journal of Bronchology; 9/19/2023, Vol. 17 Issue 1, p1-9, 9p
Abstrakt: Context: Respiratory support is an essential part in treating COVID-19 patients at risk for developing respiratory failure, and this become certain if associated with other comorbidities specifically obstructive sleep apnea (OSA). Aim: To evaluate the role of early use of continuous positive airway pressure (CPAP) in management of moderate to severe COVID-19 patients at risk of OSA. Settings and design: This was experimental clinical trial. Patients and methods: Eighty (80) patients with moderate to severe COVID-19 at risk of OSA were enrolled. They were simply randomized into two equal groups: non-CPAP group and CPAP group. Non-CPAP group will receive medical treatment plus oxygen therapy according to recommendation of protocol of the Egyptian Ministry of Health 2020 and CPAP group as in non-CPAP group plus using CPAP. Results: Our findings showed that there were higher percentages in hospital deaths and longer duration of hospital stay as well as increased need for invasive mechanical ventilation in non-CPAP group compared to CPAP group patients: (P-value = 0.03), (P-value = 0.04), and (P-value = 0.01), respectively. Also, there was a significant difference on PH, CO2, HCO3, and D-dimer values on both groups on admission and during follow-up with notable decrease in their values in CPAP group compared to non-CPAP group: (P-value = 0.04), (P-value = 0.003), (P-value = 0.001), and (P-value = 0.001), respectively. Conclusion: Early CPAP therapy for moderate and severe COVID-19 hospitalized patients with risk of OSA could improve patient's survival, shorten hospital stay, and decrease need for invasive mechanical ventilation. Trial registration: Clinicaltrials.gov/NCT05934916. Registered 6 July 2023 — retrospectively registered. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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