| Autor: |
Telek, András, Molnár, Zsófia, Vértessy, Beáta G., Tasnádi, Gábor |
| Zdroj: |
Biotechnology & Bioengineering; Oct2023, Vol. 120 Issue 10, p2793-2808, 16p |
| Abstrakt: |
Opines and opine‐type chemicals are valuable natural products with diverse biochemical roles, and potential synthetic building blocks of bioactive compounds. Their synthesis involves reductive amination of ketoacids with amino acids. This transformation has high synthetic potential in producing enantiopure secondary amines. Nature has evolved opine dehydrogenases for this chemistry. To date, only one enzyme has been used as biocatalyst, however, analysis of the available sequence space suggests more enzymes to be exploited in synthetic organic chemistry. This review summarizes the current knowledge of this underexplored enzyme class, highlights key molecular, structural, and catalytic features with the aim to provide a comprehensive general description of opine dehydrogenases, thereby supporting future enzyme discovery and protein engineering studies. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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