| Autor: |
Verma, Vineet, Maikhuri, Vipin K., Chahal, Varun |
| Předmět: |
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| Zdroj: |
Synthetic Communications; 2023, Vol. 53 Issue 16, p1339-1350, 12p, 2 Color Photographs, 1 Diagram, 5 Charts, 3 Graphs |
| Abstrakt: |
A simple and convenient methodology has been developed for the synthesis of β-amino alcohols from native sugar D-glucose. First, D-glucose was converted into 2,6-anhydro-3,4,5,7-tetra-O-benzyl-heptitol which was then converted into its corresponding epoxide. Finally, the epoxide was reacted with variety of amines in the presence of samarium (III) trifluoromethanesulfonate to afford b-amino alcohols regioselectively in excellent yields of 90-95% followed by debenzylation to afford hydroxylated derivatives. Additionally, molecular docking studies of the synthesized compounds considering β1- and β2-adrenoreceptors as target structures were performed. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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