| Autor: |
Singh, Rakesh, Kaur, Harpreet, Gupta, Pankaj |
| Předmět: |
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| Zdroj: |
AIP Conference Proceedings; 2023, Vol. 2800 Issue 1, p1-23, 23p |
| Abstrakt: |
Alzheimer's disease (AD) is an intricate neurological disorder in which degeneration of brain cells occurs. A recent study has demonstrated that around thirty-six million people are affected with AD. It has been found that the number of deaths due to Alzheimer's disease increased 146.2% between 2000 and 2018. The various evidence collected till date, indicate that β-amyloid is pivotal to the pathogenesis of AD and hence is main factor responsible for AD. The BACE1 enzyme is essential for the generation of β-amyloid and it has been found that level of BACE1 increases in persons with AD. The abnormal proteins distort the neurons. Moreover, as brain cells become affected, the level of neurotransmitters (chemical messengers), between the brain cells which are involved in transmitting signals in the brain decreases. Hence, researcher's need to consider various factors which cause Alzheimer's disease so that a well-defined approach can be adopted for focused drug discovery and development. As AD is a highly complex neurological disorder, therefore the researchers need to adopt a synthetic approach which is "Multi-Target-Directed Ligand". The present review is based on the major advancements in the synthesis of compounds containing 1,2,3-triazole pharmacophore as cholinesterase (AChE and BuChE) inhibitors as well as (BACE1) inhibitors for the period 2007 to 2020. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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