Neurological and psychiatric disorders among autistic adults: a population healthcare record study.
| Autor: | Underwood, Jack F. G., DelPozo-Banos, Marcos, Frizzati, Aura, Rai, Dheeraj, John, Ann, Hall, Jeremy |
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| Předmět: |
PSYCHIATRIC epidemiology
PUBLIC health surveillance NEUROLOGICAL disorders NOSOLOGY RETROSPECTIVE studies CASE-control method MENTAL health COGNITION SOCIAL isolation COMPARATIVE studies AUTISM DESCRIPTIVE statistics RESEARCH funding ELECTRONIC health records LONGEVITY ODDS ratio LONGITUDINAL method COMORBIDITY DISEASE complications ADULTS |
| Zdroj: | Psychological Medicine; Sep2023, Vol. 53 Issue 12, p5663-5673, 11p |
| Abstrakt: | Background: Co-occurring psychiatric disorders are common in autism, with previous studies suggesting 54–94% of autistic individuals develop a mental health condition in their lifetime. Most studies have looked at clinically-recruited cohorts, or paediatric cohorts followed into adulthood, with less known about the autistic community at a population level. We therefore studied the prevalence of co-occurring psychiatric and neurological conditions in autistic individuals in a national sample. Methods: This retrospective case-control study utilised the SAIL Databank to examine anonymised whole population electronic health record data from 2001 to 2016 in Wales, UK (N = 3.6 million). We investigated the prevalence of co-occurring psychiatric and selected neurological diagnoses in autistic adults' records during the study period using International Classification of Diseases-10 and Read v2 clinical codes compared to general population controls matched for age, sex and deprivation Results: All psychiatric conditions examined were more common amongst adults with autism after adjusting for age, sex and deprivation. Prevalence of attention-deficit hyperactivity disorder (7.00%), bipolar disorder (2.50%), obsessive-compulsive disorder (3.02%), psychosis (18.30%) and schizophrenia (5.20%) were markedly elevated in those with autism, with corresponding odds ratios 8.24–10.74 times the general population. Depression (25.90%) and anxiety (22.40%) were also more prevalent, with epilepsy 9.21 times more common in autism. Conclusions: We found that a range of psychiatric conditions were more frequently recorded in autistic individuals. We add to understanding of under-reporting and diagnostic overshadowing in autism. With increasing awareness of autism, services should be cognisant of the psychiatric conditions that frequently co-occur in this population. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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