Cobalt‐Catalyzed, 2‐Aminopyridine‐N‐Oxide‐Directed C(sp2)−H Bond Functionalization with Maleimides: Facile Access to Isoindolone Spirosuccinimides.

Autor:	Patel, Raj N., Patel, Dharmik M., Rathod, Nileshkumar B., Thakur, Dinesh G., Patel, Sachinkumar D., Tothadi, Srinu, Ghosh, Subhash Chandra
Předmět:	MALEIMIDES RING formation (Chemistry) COBALT BONDS (Finance) FUNCTIONAL groups BENZAMIDE
Zdroj:	European Journal of Organic Chemistry; 9/6/2023, Vol. 26 Issue 34, p1-6, 6p
Abstrakt:	A cobalt‐catalyzed, N,O‐bidentate directing group‐assisted C−H bond functionalization of benzamides with maleimides was developed for the facile access to isoindolone spirosuccinimides in good to excellent yields. This C−H bond activation and spirocyclization employing pyridine N‐oxide as directing group provided very good substrate scope and tolerated various functional groups. Furthermore, the mechanistic investigation revealed that the C−H bond activation is the rate‐determining step of this reaction. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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