| Autor: |
Bell, Thomas D. |
| Předmět: |
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| Zdroj: |
Clinical Pediatrics; Jul1971, Vol. 10 Issue 7, p380-384, 5p |
| Abstrakt: |
The article focuses on an epidemic of acute glomerulonephritis in Hawaii. The apparent immunologic pathogenesis of glomerulonephritis provides one of the best screening tests for the identification of acute nephritis. Serum beta-1-C complement is consumed physiologically, so that its level is reduced in acute glomerulonephritis as well as in many immunologic diseases. Such studies with 40 patients showed that at least 90 per cent had significantly lowered beta-1-C values. Serum protein electrophoresis also portrayed heightened immunologic activity: ten of 12 patients had alpha-2 elevations and eight of 12 had gamma globulin elevations. Antibiotic therapy of the infection preceding the onset of nephritis seemed to attenuate the course of the illness. No predominant portal of entry was found. Of the Group A beta-hemolytic streptococcal isolates, 28 per cent were from the skin. This relatively small proportion is surprising in a damp climate with rampant impetigo such as in Hawaii. However, difficulty in culturing dry and crusted skin lesions could account for many missed cultures. |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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