| Autor: |
Karip, Burak, Köse, Özlem Öztürk, Seykan, Heval Helin, Akpınar, Yunus Emre, Keleş, Papatya |
| Předmět: |
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| Zdroj: |
Journal of Academic Research in Medicine; 2023, Vol. 13 Issue 2, p76-81, 6p |
| Abstrakt: |
Objective: Magnetic resonance (MR) imaging techniques are at the center of studies on multiple sclerosis (MS), an autoimmune disorder characterized by demyelination and neurodegeneration in the central nervous system. We aimed to show the differences in the white matter (WM) and cerebrospinal fluid (CSF) volumes in addition to the frontal, temporal, and occipital lobes (OLs) in MS disease and their relations with each other through MR images. Methods: Images of 50 MS and 50 control group patients randomly selected for use in our study were obtained from Biruni University Faculty of Medicine. Using volBrain software, the volumes of brain structures were calculated on T1-weighted MR images in accordance with the determined parameters. Data analysis was performed using the IBM SPSS 25 package programs. Results: Volumetric calculations with statistically significant results between groups: abnormal appearance white matter (AaWM) (p<0.001), total volume of WM and gray matter (WMGM) (p=0.001), CSF (p=0.002) and frontal lobe (FL) (p=0.024) volumes. Parameters with high correlation according to correlation analysis; WMGM-CSF (r=0.999), FL supplementary motor cortex (SMC) (r=0.742), FL-temporal lobe (TL) (r=0.827), FL-temporal pole (TP) (r=0.652), SMC-TL (r=0.663), TL-TP (r=0.875), OL-occipital pole (r=0.649) and FL-frontal pole (r=0.686) volumes. Conclusion: The presence of a decrease in FL and WM against the volumetric increase in AaWM and CSF is the most important of the predicted and significant results in this study. The fact that the significance levels in other parameters are comparatively low indicates that further studies should focus on more specific structures and methods, and all the results obtained can give clinicians a clue for the diagnosis step of MS disease. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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