Association of the rs1344706 Polymorphism of the ZNF804A Gene with Induced EEG Rhythm Changes during Visual Perception of Verbal Stimuli in Healthy and Schizophrenic Subjects.

Autor: Garakh, Zh. V., Golimbet, V. E., Larionova, E. V., Lezheiko, T. V., Strelets, V. B., Zaytseva, Yu. S.
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Zdroj: Neuroscience & Behavioral Physiology; Jun2023, Vol. 53 Issue 5, p846-855, 10p
Abstrakt: The association of the rs1344706 polymorphism of the ZNF804A gene with EEG rhythm synchronization/ desynchronization parameters during the visual perception of semantic and meaningless verbal information was studied in patients with schizophrenia and schizophrenia spectrum disorders (n = 93) and mentally healthy subjects (n = 93). On reading verbal information, regardless of mental status, subjects with the AA genotype showed lower synchronization of the θ rhythm than carriers of the C allele. As compared with carriers of the C allele, healthy carriers of the AA allele showed lower synchronization of the θ rhythm in the posterior cortical areas of the left hemisphere, no difference in synchronization of the γ rhythm, and desynchronization of the μ rhythm on perception of semantic and meaningless verbal information. Patients carrying the AA variant, as compared with carriers of the C variant, showed a lower degree of μ-rhythm desynchronization, which correlated with the severity of speech disorders on the PANSS. The results obtained here indicate that the rs1344706 polymorphism of the ZNF804A gene has a modulating effect on the neurophysiological characteristics of the reading process and contributes to the variability of clinically expressed speech disorders. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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